The role of blood from HLA-homozygous donors in fatal transfusion-associated graft-versus-host disease after open-heart surgery.

@article{Thaler1989TheRO,
  title={The role of blood from HLA-homozygous donors in fatal transfusion-associated graft-versus-host disease after open-heart surgery.},
  author={Michael M. Thaler and Ari Shamiss and Shlomit Orgad and Monica Huszar and Naomi Nussinovitch and S{\'a}ndor Meisel and Ehud Gazit and Jacob Lavee and Aram Kurt Smolinsky},
  journal={The New England journal of medicine},
  year={1989},
  volume={321 1},
  pages={
          25-8
        }
}
Acute graft-versus-host disease has been described in immunocompromised patients receiving nonirradiated blood products.1 2 3 In addition to the involvement of the skin, liver, and gut typically seen in graft-versus-host disease after bone marrow transplantation,4 these patients have bone marrow involvement that results in pancytopenia. The aplasia observed in graft-versus-host disease is presumably due to recognition by the donor's immune-reactive cells of histoincompatible antigens on the… CONTINUE READING
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