The role of bisphosphonates in breast and prostate cancers.

  title={The role of bisphosphonates in breast and prostate cancers.},
  author={Janet Elizabeth Brown and Helen L. Neville-Webbe and Robert Coleman},
  journal={Endocrine-related cancer},
  volume={11 2},
Bisphosphonate drugs are a group of pyrophosphate analogues which bind avidly to hydroxyapatite bone mineral surfaces and their major action is to inhibit osteoclast activity and thus bone resorption. In oncology, their role in metastatic bone disease is well established, but there is increasing interest in their potential role in preventing and treating cancer-induced bone loss and their possible anti-tumour effects. Metastatic bone disease is associated with a variety of skeletal… CONTINUE READING


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Pamidronate to prevent bone loss in men receiving gonadotropin releasing hormone agonist therapy for prostate cancer

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