BACKGROUND Bone metastasis is very frequent in prostate cancer. It is a turning point that marks the severity of the disease. Before metastasis become symptomatic, treatment preventing bone events should be indicated. AIM To evaluate the role of bisphosphonate in the treatment of bone metastases from prostate cancer. METHODS A review of literature. RESULTS Bisphosphonates play a very important role to prevent bone mass loss and to reduce bone complication events. CONCLUSION Bisphosphonates are recommended as preventive treatment at the time of diagnosis of bone metastatic prostate cancer.