The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.

Abstract

BACKGROUND Ingestion of aristolochic acid (AA) is associated with the development of aristolochic acid nephropathy (AAN), which is characterized by chronic renal failure, tubulointerstitial fibrosis and urothelial cancer. AA may also cause another type of kidney fibrosis with malignant transformation of the urothelium, called Balkan Endemic Nephropathy (BEN… (More)

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@article{Stiborov2009TheRO, title={The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.}, author={Marie Stiborov{\'a} and Eva Frei and Volker M Arlt and Heinz Hans Schmeiser}, journal={Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia}, year={2009}, volume={153 1}, pages={5-11} }