The role of biotransformation and oxidative stress in 3,5-dichloroaniline (3,5-DCA) induced nephrotoxicity in isolated renal cortical cells from male Fischer 344 rats.

@article{Racine2016TheRO,
  title={The role of biotransformation and oxidative stress in 3,5-dichloroaniline (3,5-DCA) induced nephrotoxicity in isolated renal cortical cells from male Fischer 344 rats.},
  author={Christopher Robert Racine and Travis Ferguson and Debbie Preston and Dakota James Ward and John Greg Ball and Dianne K. Anestis and Monica A Valentovic and Gary O. Rankin},
  journal={Toxicology},
  year={2016},
  volume={341-343},
  pages={
          47-55
        }
}
Among the mono- and dichloroanilines, 3,5-dichloroaniline (3,5-DCA) is the most potent nephrotoxicant in vivo and in vitro. However, the role of renal biotransformation in 3,5-DCA induced nephrotoxicity is unknown. The current study was designed to determine the in vitro nephrotoxic potential of 3,5-DCA in isolated renal cortical cells (IRCC) obtained from male Fischer 344 rats, and the role of renal bioactivation and oxidative stress in 3,5-DCA nephrotoxicity. IRCC (∼ 4 million cells/ml) from… CONTINUE READING
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