The role of biotransformation and bioactivation in toxicity.

@article{Dekant2009TheRO,
  title={The role of biotransformation and bioactivation in toxicity.},
  author={Wolfgang Dekant},
  journal={EXS},
  year={2009},
  volume={99},
  pages={57-86}
}
Biotransformation is essential to convert lipophilic chemicals to water-soluble and readily excretable metabolites. Formally, biotransformation reactions are classified into phase I and phase II reactions. Phase I reactions represent the introduction of functional groups, whereas phase II reactions are conjugations of such functional groups with endogenous, polar products. Biotransformation also plays an essential role in the toxicity of many chemicals due to the metabolic formation of toxic… CONTINUE READING