The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function.

@inproceedings{Kidd2001TheRO,
  title={The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function.},
  author={Richard D. Kidd and J. E. Russell and Nicholas J Watmough and Edward N Baker and Thomas Brittain},
  year={2001}
}
By using transgenic methodologies, we have produced a number of mouse/human chimeric hemoglobins containing adult mouse and human embryonic globin chains. A detailed analysis of the oxygen binding properties of these proteins identifies the dominant role played by the specific β-type globin chains in the control of the oxygen binding characteristics. Further analysis traces the origins of these effects to alterations in the properties of the T states of these proteins. The human ζ/mouse… CONTINUE READING

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