The role of beta(3)-adrenoceptors in mediating relaxation of porcine detrusor muscle.

@article{Yamanishi2002TheRO,
  title={The role of beta(3)-adrenoceptors in mediating relaxation of porcine detrusor muscle.},
  author={Tomonori Yamanishi and Christopher R Chapple and Kosaku Yasuda and Kenichiro Yoshida and Russell Chess-Williams},
  journal={British journal of pharmacology},
  year={2002},
  volume={135 1},
  pages={
          129-34
        }
}
1. beta-adrenoceptors mediate relaxation of bladder detrusor smooth muscle. This study investigates the contribution of beta(3)-adrenoceptors to relaxation of the pig urinary bladder. 2. Cell membranes were prepared from detrusor muscle of the pig bladder dome and competition experiments with [(3)H]-dihydroalprenolol (DHA), a non-selective beta-adrenoceptor antagonist was used as a specific radioligand to determine the presence of beta-adrenoceptor subtypes. In functional experiments, isolated… CONTINUE READING

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