The role of benzodiazepine receptors in the induction of differentiation of HL-60 leukemia cells by benzodiazepines and purines.

@article{Ishiguro1987TheRO,
  title={The role of benzodiazepine receptors in the induction of differentiation of HL-60 leukemia cells by benzodiazepines and purines.},
  author={Kimiko Ishiguro and William C. Taft and Robert J Delorenzo and Alan C. Sartorelli},
  journal={Journal of cellular physiology},
  year={1987},
  volume={131 2},
  pages={226-34}
}
A series of benzodiazepines was evaluated for their capacity to induce the differentiation of HL-60 acute promyelocytic leukemia cells. Benzodiazepines were effective initiators of maturation in the concentration range of 50 to 150 microM. The possible involvement of benzodiazepine receptors in mediating the differentiation induced by these agents was investigated. The presence of high affinity, peripheral type benzodiazepine binding sites (KD = 7.3 nM, TB = 14.5 pmol/mg protein with Ro5-4864… CONTINUE READING