The role of baculovirus apoptotic suppressors in AcMNPV-mediated translation arrest in Ld652Y cells.

@article{Thiem2004TheRO,
  title={The role of baculovirus apoptotic suppressors in AcMNPV-mediated translation arrest in Ld652Y cells.},
  author={Suzanne M. Thiem and Nor Chejanovsky},
  journal={Virology},
  year={2004},
  volume={319 2},
  pages={
          292-305
        }
}
Infecting the insect cell line IPLB-Ld652Y with the baculovirus Autographa californica multinucleocapsid nucleopolyhedrovirus (AcMNPV) results in global translation arrest, which correlates with the presence of the AcMNPV apoptotic suppressor, p35. In this study, we investigated the role of apoptotic suppression on AcMNPV-induced translation arrest. Infecting cells with AcMNPV bearing nonfunctional mutant p35 did not result in global translation arrest. In contrast, global translation arrest… CONTINUE READING
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