The role of bacterial biofilms in device-associated infection.

  title={The role of bacterial biofilms in device-associated infection.},
  author={Anand K Deva and William P. Adams and Karen Vickery},
  journal={Plastic and reconstructive surgery},
  volume={132 5},
There is increasing evidence that bacterial biofilm is responsible for the failure of medical devices, leading to device-associated infection. As plastic surgeons, we are among the leading users of prostheses in surgery, and it is important that we are kept informed of this growing problem. This article summarizes the pathogenesis of device-associated infection, outlines the evidence for such infection in a number of medical devices, and outlines operative strategies aimed at reducing the risk… 

Targeting biofilms in medical devices using probiotic cells: a systematic review

It is demonstrated that probiotic cells have the potential to be used as biocontrol agents against biofilm formation by a broad spectrum of microorganisms.

Microbial biofilm in human health - an updated theoretical and practical insight

The mechanisms involved in biofilm development, biofilm related infections, methods of detection and quantification of microbial communities and therapeutical approaches are described.

Biofilms in Human Diseases: Treatment and Control

This chapter explains bacterial biofilm formation and composition and considers many of the harmful and beneficial effects of bacterial biofilms, and contemplates control strategies and the future of bacteria.

Biofilm-Mediated Diseases of the Heart and Lungs

  • Surojeet Das
  • Biology, Medicine
    Biofilms in Human Diseases: Treatment and Control
  • 2019
Fungal and bacterial biofilms play significant roles in a variety of pulmonary and heart diseases, of which cystic fibrosis lung disease, pneumonia caused by ventilators, infective endocarditis, pulmonary infections, and atherosclerosis are noteworthy.

The Use of Probiotics to Fight Biofilms in Medical Devices: A Systematic Review and Meta-Analysis

Probiotics and their products is a promising strategy to hinder biofilm growth by a broad spectrum of pathogenic microorganisms using a PRISMA-oriented systematic search and meta-analysis.

The Role of Bacterial Biofilm in Adverse Soft-Tissue Filler Reactions: A Combined Laboratory and Clinical Study

Filler material can support the growth of bacterial biofilm in vitro and multiple needle passes can significantly increase the risk of filler contamination, which is associated with high numbers in clinical samples of patients presenting with chronic granulomatous inflammation.

What is the best technic to dislodge Staphylococcus epidermidis biofilm on medical implants?

The US procedure was the best technic to dislodge S. epidermidis biofilm on silicone, piccline, peripheral venous catheter but not endotracheal tube, and depending on the materials used, the biofilm dislodging technique must be adapted.

Reply: The Role of Bacterial Biofilm in Adverse Soft-Tissue Filler Reactions: A Combined Laboratory and Clinical Study.

  • A. Deva
  • Medicine
    Plastic and reconstructive surgery
  • 2017
The findings and conclusions in this communication have not been formally disseminated by the U.S. Food and Drug Administration and should not be construed to represent any Agency determination or policy.

Discussion: Doxycycline-Coated Silicone Breast Implants Reduce Acute Surgical-Site Infection and Inflammation.

The authors demonstrate that 3 and 7 days after infection, doxycycline-coated implants show promise at reducing the number of bacteria capable of infecting the implants compared with uncoated, infected controls, and this suggests that cytokine production is dictated by infection, and when infection is reduced, cytokine expression matches that induced by control implants.

Functionalized Self-Assembled Monolayers: Versatile Strategies to Combat Bacterial Biofilm Formation

This review focuses on the use of SAMs to inhibit biofilm formation, both on their own and by covalent grafting of a biocidal agent, with the potential to be used in indwelling medical devices.



Infections associated with medical devices: pathogenesis, management and prophylaxis.

Specific guidelines comprising both technological and nontechnological strategies for prevention have been established and further studies are needed to translate the knowledge on the mechanisms of biofilm formation into applicable therapeutic and preventive strategies.

Bacterial biofilms: influence on the pathogenesis, diagnosis and treatment of urinary tract infections.

The role of bacterial biofilm formation in catheter-associated infection, prostatitis and struvite (infected stone) calculogenesis stressing, and the importance ofacterial biofilms in the pathogenesis, persistence and hence the treatment of urinary tract infection are reviewed.

Staphylococcus epidermidis device‐related infections: pathogenesis and clinical management

This review will examine the pathogenesis of the clinically significant S. epidermidis and provide an overview of the conventional and emerging antibiofilm approaches in the management of medical device‐associated infections related to this important nosocomial pathogen.

The Challenge of Treating Biofilm‐associated Bacterial Infections

This work has shown that Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents, which is key to development of new therapeutic strategies.

Biofilms in device-related infections

The diagnosis and management of biofilm-associated infections remain difficult but critical issues and Appropriate antimicrobial therapy is often not effective in eradicating these infections and the removal of the device becomes necessary.

Bacterial biofilms: a diagnostic and therapeutic challenge

This review discusses the shortcomings of current therapies against biofilms both in theory and with clinical examples and describes biofilm characteristics with a focus on new diagnostic and therapeutic targets.

Molecular and Imaging Techniques for Bacterial Biofilms in Joint Arthroplasty Infections

Molecular diagnostic and confocal imaging techniques to identify and characterize biofilms associated with infected implants are developed and PCR and reverse transcription (RT)-PCR-based assays that can be used to detect bacterial infections associated with culture-negative joint effusions that distinguish between physiologically active Staphylococcus aureus and Staphyllococcus epidermidis are designed.

Biofilm theory can guide the treatment of device-related orthopaedic infections.

It is realized that these orthopaedic infections are caused by relatively common biofilm-forming bacterial pathogens, new technologies that deliver very high concentrations of antibiotics locally and "on demand" and novel molecular "mimics" that block the signals that control biofilm formation need to be examined.

Biofilm-related infections in ophthalmology

The pathophysiology of biofilms and their application of ophthalmology is reviewed, finding that biofilm is an important cause of infections associated with biomaterials.

Correlation between enterococcal biofilm formation in vitro and medical-device-related infection potential in vivo.

The ability of E. faecalis isolates to form biofilm in vitro appears to be a marker of a virulence trait that enhances the ability of isolates from different sources of infection to cause CRBSI.