The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers.

@article{Wang2014TheRO,
  title={The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers.},
  author={Shaofei Wang and Yubin Li and Jiajun Fan and Ziyu Wang and Xian Zhi Zeng and Yun Sun and Ping Song and Dianwen Ju},
  journal={Biomaterials},
  year={2014},
  volume={35 26},
  pages={
          7588-97
        }
}
Poly(amidoamine) (PAMAM) dendrimers, are among the most common classes of dendrimers that are intended for a wide range of biomedical applications and extensively investigated for brain-specific drug delivery, imaging and diagnosis. Unfortunately, neurotoxicity of PAMAM dendrimers, the underlying mechanism of which is poorly-elucidated, poses a far-reaching challenge to their practical applications. In this study, we reported that PAMAM dendrimers induced both cytotoxicity and autophagic flux… CONTINUE READING

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