The role of autophagy in neurodegenerative disease

  title={The role of autophagy in neurodegenerative disease},
  author={Ralph A. Nixon},
  journal={Nature Medicine},
Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and protein aggregates. These substrates reach lysosomes by several distinct mechanisms, including delivery within endosomes as well as autophagosomes. Completion of digestion involves dynamic interactions among compartments of the autophagic and endocytic pathways. Neurons are particularly vulnerable to disruptions of these interactions, especially as the brain ages. Not… CONTINUE READING
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