The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

@article{Nakai2007TheRO,
  title={The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress},
  author={Atsuko Nakai and Osamu Yamaguchi and Toshihiro Takeda and Yoshiharu Higuchi and Shungo Hikoso and Masayuki Taniike and Shigemiki Omiya and Isamu Mizote and Yasushi Matsumura and Michio Asahi and Kazuhiko Nishida and Masatsugu Hori and Noboru Mizushima and Kinya Otsu},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={619-624}
}
Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism in starving cells. Although altered autophagy has been observed in various heart diseases, including cardiac hypertrophy and heart failure, it remains unclear whether autophagy plays a beneficial or detrimental role in the heart. Here, we report that the cardiac-specific loss of autophagy causes cardiomyopathy in mice. In adult mice, temporally controlled… CONTINUE READING
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