The role of autophagy in Parkinson's disease☆

Abstract

Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation.

DOI: 10.3969/j.issn.1673-5374.2012.02.011

Cite this paper

@inproceedings{Zhang2012TheRO, title={The role of autophagy in Parkinson's disease☆}, author={Lei Zhang and Yaru Dong and Xiaoheng Xu and Zhong Xu}, booktitle={Neural regeneration research}, year={2012} }