The role of autophagy in Paneth cell differentiation and secretion

  title={The role of autophagy in Paneth cell differentiation and secretion},
  author={Thaddeus S Stappenbeck},
  journal={Mucosal Immunology},
Paneth cells are a small intestinal epithelial cell lineage that is considered to have a role in innate immune function. Recent studies on mice with diminished and/or loss of autophagy have suggested that Paneth cells are a primary target in vivo. Interestingly, loss of autophagy affects the secretion of antimicrobial proteins from Paneth cells. Understanding the intersection of the autophagy pathway with the secretory apparatus, which is a key feature of differentiation of Paneth cells, is a… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 10 references

A key role for autophagy and the autophagy gene Atg 16 l 1 in mouse and human intestinal Paneth cells

  • K. Cadwell
  • Nature
  • 2008

Similar Papers

Loading similar papers…