The role of autophagy during the early neonatal starvation period

  title={The role of autophagy during the early neonatal starvation period},
  author={Akiko Kuma and Masahiko Hatano and Makoto Matsui and Akitsugu Yamamoto and Haruaki Nakaya and Tamotsu Yoshimori and Yoshinori Ohsumi and Takeshi Tokuhisa and Noboru Mizushima},
At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constituents within lysosomes. The level of autophagy in mice remains low during embryogenesis; however, autophagy is immediately upregulated in various tissues after birth and is… 
The role of autophagy in neonatal tissues: Just a response to amino acid starvation?
Autophagy is activated soon after birth in neonatal tissues and is essential for survival because mice deficient in Atg5 or Atg7 autophagy genes die within 1 day after birth, but may have other important functions in Neonatal physiology, including glycogen degradation, programmed cell remodeling and response to oxidative stress.
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