The role of autophagy during the early neonatal starvation period

@article{Kuma2004TheRO,
  title={The role of autophagy during the early neonatal starvation period},
  author={Akiko Kuma and Masahiko Hatano and Makoto Matsui and Akitsugu Yamamoto and Haruaki Nakaya and Tamotsu Yoshimori and Yoshinori Ohsumi and Takeshi Tokuhisa and Noboru Mizushima},
  journal={Nature},
  year={2004},
  volume={432},
  pages={1032-1036}
}
At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients. Here, we show that neonates adapt to this adverse circumstance by inducing autophagy. Autophagy is the primary means for the degradation of cytoplasmic constituents within lysosomes. The level of autophagy in mice remains low during embryogenesis; however, autophagy is immediately upregulated in various tissues after birth and is… 
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