The role of arginase in the immune response.

@article{Schneider1985TheRO,
  title={The role of arginase in the immune response.},
  author={Elke Schneider and Michel Dy},
  journal={Immunology today},
  year={1985},
  volume={6 4},
  pages={136-40}
}
Arginase activity - mainly known for its involvement in urea formation in the liver - inhibits DNA synthesis in cultured mammalian cells(1). Arginase is synthesised and released by activated macrophages mediating immunosuppression during mixed leucocyte culture(2) and may be implicated in macrophage cytotoxicity during the anti-tumor(3), anti-parasite(4) and anti-viral(5) responses. Here Elke Schneider and Michel Dy discuss these aspects of arginase activity as well as more recent indications… CONTINUE READING