The role of apoptosis in thyroid autoimmunity.

  title={The role of apoptosis in thyroid autoimmunity.},
  author={Su He Wang and James R Baker},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={17 10},
There is increasing evidence showing that apoptosis plays a role in the development of the autoimmune thyroid diseases-Hashimoto's (lymphocytic) thyroiditis (HT) and Graves' disease (GD). The immune pathogenesis of HT and GD is not yet fully understood, but evidence points toward several steps. A defect in CD4(+)CD25(+) T regulatory cells breaks the immunological tolerance of the host and induces an abnormal production of cytokines, which facilitates the initiation of apoptosis. Though… CONTINUE READING