The role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transfer.

@article{Faust2013TheRO,
  title={The role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transfer.},
  author={Susan M. Faust and Peter Bell and Yanqing Zhu and Julio C. Sanmiguel and James Michael Wilson},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013},
  volume={21 12},
  pages={2227-35}
}
Gene therapy provides a significant opportunity to treat a variety of inherited and acquired diseases. However, adverse immune responses toward the adeno-associated virus (AAV) antigens may limit its success. The mechanisms responsible for immunity or tolerance toward AAV-encoded transgene products remain poorly defined. Studies in mice demonstrate that AAV2/8 gene transfer to liver is associated with immunological hyporesponsiveness toward both AAV vector and antigenic transgene product. To… CONTINUE READING
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