The role of apoptosis in defense against baculovirus infection in insects.

@article{Clem2005TheRO,
  title={The role of apoptosis in defense against baculovirus infection in insects.},
  author={Rollie J. Clem},
  journal={Current topics in microbiology and immunology},
  year={2005},
  volume={289},
  pages={113-29}
}
  • Rollie J. Clem
  • Published 2005 in Current topics in microbiology and immunology
The baculoviruses make up a large, diverse family of DNA viruses that have evolved a number of fascinating mechanisms to manipulate their insect hosts. One of these is the ability to regulate apoptosis during infection by expressing proteins that can inhibit caspase activation and/or activity, including the caspase inhibitor P35 and its relatives, and the inhibitor of apoptosis (IAP) proteins. Experimental manipulations of the expression of these antiapoptotic genes, either by genetic deletions… CONTINUE READING

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