The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis.

@article{Shubar2009TheRO,
  title={The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis.},
  author={Hend M. Shubar and Ildiko Rita Dunay and Sabrina M. Lachenmaier and Margitta Dathe and Faris Nadiem Bushrab and Rachmat Mauludin and Rainer Helmut M{\"u}ller and Rudolf G Fitzner and Klaus Borner and Oliver Liesenfeld},
  journal={Journal of drug targeting},
  year={2009},
  volume={17 4},
  pages={
          257-67
        }
}
We investigated whether coating of atovaquone nanosuspensions (ANSs) with apolipoprotein E (apoE) peptides improves the uptake of atovaquone into the brain. The passage across the blood-brain barrier (BBB) of ANSs stabilized by polysorbate 80 (Tween 80), poloxamer 184 (P184), or poloxamer 338 (P338) and the same formulations coated with apoE peptides were analyzed in vitro and in vivo. Passage through a rat coculture model of the BBB did not differ between individual atovaquone formulations… CONTINUE READING

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