The role of apolipoprotein AI domains in lipid binding.

  title={The role of apolipoprotein AI domains in lipid binding.},
  author={W. Sean Davidson and Theodore Hazlett and William W. Mantulin and Ana Jonas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 24},
Apolipoprotein AI (apoAI) is the principal protein constituent of high density lipoproteins and it plays a key role in human cholesterol homeostasis; however, the structure of apoAI is not clearly understood. To test the hypothesis that apoAI is organized into domains, three deletion mutants of human apo AI expressed in Escherichia coli were studied in solution and in reconstituted high density lipoprotein particles. Each mutant lacked one of three specific regions that together encompass… CONTINUE READING

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