The role of anticytokine therapy in heart failure: recent lessons from preclinical and clinical trials?

@article{Feldman2003TheRO,
  title={The role of anticytokine therapy in heart failure: recent lessons from preclinical and clinical trials?},
  author={Arthur M Feldman and Toshiaki Kadokami and Yoshiro Higuichi and Ravi S. Ramani and Charles F McTiernan},
  journal={The Medical clinics of North America},
  year={2003},
  volume={87 2},
  pages={
          419-40
        }
}
In summary, over a decade of investigation has demonstrated the pathophysiologic importance of TNF in the development and progression of cardiac dilatation and heart failure. Although the signaling pathways that regulate the cardiac production of TNF have not yet been identified and the potential benefits of TNF expression to the heart are not understood, the benefits of anticytokine therapy in animal models is marked. Unfortunately, these salutary effects in the laboratory have not… CONTINUE READING
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