The role of antibodies in multiple sclerosis.

@article{Weber2011TheRO,
  title={The role of antibodies in multiple sclerosis.},
  author={Martin S. Weber and Bernhard Hemmer and Sabine Cepok},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1812 2},
  pages={239-45}
}
B cells, plasma cells, and antibodies are commonly found in active central nervous system (CNS) lesions in patients with multiple sclerosis (MS). B cells isolated from CNS lesions as well as from the cerebrospinal fluid (CSF) show signs of clonal expansion and hypermutation, suggesting their local activation. Plasma blasts and plasma cells maturating from these B cells were recently identified to contribute to the development of oligoclonal antibodies produced within the CSF, which remain a… CONTINUE READING
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