The role of anti-HLA antibodies in hematopoietic stem cell transplantation.

@article{Focosi2011TheRO,
  title={The role of anti-HLA antibodies in hematopoietic stem cell transplantation.},
  author={Daniele Focosi and Alessandra Zucca and Fabrizio Scatena},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2011},
  volume={17 11},
  pages={
          1585-8
        }
}
Donor-specific antihuman leukocyte antigen antibodies (DSHA) have been clearly implicated in graft rejection in solid organ transplantation. Their role in allogeneic hematopoietic stem-cell transplantation (allo-HSCT) remains unclear. We summarize here evidence supporting a role for DSHA in graft failure in animal models of allo-HSCT and in clinical settings whenever no full HLA matching occurs. 
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