The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants.

@article{Streblow2008TheRO,
  title={The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants.},
  author={Daniel N Streblow and Craig N. Kreklywich and Takeshi F. Andoh and Ashlee V Moses and Jerome Dumortier and Patricia P. Smith and Victor R Defilippis and Klaus Fruh and Jay A. Nelson and Susan L. Orloff},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2008},
  volume={8 2},
  pages={277-87}
}
Human cytomegalovirus (HCMV) accelerates transplant vascular sclerosis (TVS), a consequence of angiogenesis (AG) and wound repair (WR). While HCMV can be localized to TVS lesions, the low number of infected cells suggests a global effect on target tissues. We used microarray analysis followed by real-time-polymerase chain reaction (RT-PCR) in an RCMV-accelerated TVS rat cardiac transplant model to determine whether CMV activates host WR and AG factors. Dysregulated cellular genes in allografts… CONTINUE READING