The role of angiogenesis in a murine tibial model of distraction osteogenesis.

@article{Carvalho2004TheRO,
  title={The role of angiogenesis in a murine tibial model of distraction osteogenesis.},
  author={Richarles Souza de Carvalho and Thomas A. Einhorn and Wolfgang Dipl Ing Lehmann and Cory M. Edgar and Ahmad Al-Yamani and Alexios Apazidis and Donna M. Pacicca and Thomas L. Clemens and Louis C. Gerstenfeld},
  journal={Bone},
  year={2004},
  volume={34 5},
  pages={
          849-61
        }
}
Distraction osteogenesis (DO) is one of the most dramatic in vivo applications of mechanical stimulation as a means of inducing bone regeneration. A simple and reproducible murine model of tibia distraction osteogenesis was developed using a monolateral fixator. Bone formation was assessed histologically over a 35-day time course. The steady state expression of a broad family of angiogenesis-associated genes was assessed by microarray hybridization analyses over the same time course, while the… CONTINUE READING
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