The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation.

@article{Zuloaga2008TheRO,
  title={The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation.},
  author={Damian G. Zuloaga and David Andrew Puts and Cynthia Lee Jordan and S Marc Breedlove},
  journal={Hormones and behavior},
  year={2008},
  volume={53 5},
  pages={613-26}
}
Many studies demonstrate that exposure to testicular steroids such as testosterone early in life masculinizes the developing brain, leading to permanent changes in behavior. Traditionally, masculinization of the rodent brain is believed to depend on estrogen receptors (ERs) and not androgen receptors (ARs). According to the aromatization hypothesis, circulating testosterone from the testes is converted locally in the brain by aromatase to estrogens, which then activate ERs to masculinize the… CONTINUE READING

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