The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides.

@article{Abramov2005TheRO,
  title={The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides.},
  author={Andrey Y Abramov and Michael R Duchen},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2005},
  volume={360 1464},
  pages={2309-14}
}
Amyloid beta peptide (Abeta) accumulates in the CNS in Alzheimer's disease. Both the full peptide (1-42) or the 25-35 fragment are toxic to neurons in culture. We have used fluorescence imaging technology to explore the mechanism of neurotoxicity in mixed asytrocyte/neuronal cultures prepared from rat or mouse cortex or hippocampus, and have found that Abeta acts preferentially on astrocytes but causes neuronal death. Abeta causes sporadic transient increases in [Ca2+]c in astrocytes… CONTINUE READING