The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralization.

@article{Lovelace2011TheRO,
  title={The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralization.},
  author={Erica S. Lovelace and Hengyu Xu and Catherine A. Blish and Roland K. Strong and Julie Overbaugh},
  journal={Virology},
  year={2011},
  volume={421 2},
  pages={
          235-44
        }
}
The detailed interactions between antibodies and the HIV-1 envelope protein that lead to neutralization are not well defined. Here, we show that several conservative substitutions in the envelope gp41 led to a ~100 fold increase in neutralization sensitivity to monoclonal antibodies (MAbs) that target gp41: 4E10 and 2F5. Substitution at position 675 alone did not impact neutralization susceptibility to MAbs that recognize more distal sites in gp120 (b12, VRC01, PG9). However, changes at… CONTINUE READING
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