The role of alpha1-adrenoceptors in the clonidine-induced contraction and relaxation of rat aorta.

@article{Iwanaga1998TheRO,
  title={The role of alpha1-adrenoceptors in the clonidine-induced contraction and relaxation of rat aorta.},
  author={Shiro Iwanaga and Osamu Shibata and Atsushi Tsuda and Seiji Hashimoto and Tetsuji Makita and Sungsam Cho and Koji Sumikawa},
  journal={Research communications in molecular pathology and pharmacology},
  year={1998},
  volume={102 2},
  pages={137-47}
}
Clonidine causes dilatation of the aorta in the presence of endothelium, while it causes contraction of the aorta in the absence of endothelium. The present study was carried out to clarify the role of alpha-1-adrenoceptors in the vascular action of clonidine. The aortic rings were suspended in Krebs-Henseleit (K-H) medium, and the effects of alpha-1- and alpha-2-adrenoceptor antagonists on the clonidine-induced contractions were measured. Moreover, the role of the phosphatidylinositol (PI… CONTINUE READING