The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.

@article{Theti2004TheRO,
  title={The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.},
  author={Davinder Singh Theti and Ann L. Jackman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 3},
  pages={1080-9}
}
PURPOSE Raltitrexed, pemetrexed, lometrexol, and ZD9331 are antifolate drugs transported into cells via the ubiquitously expressed reduced-folate carrier. They display also high affinity for the alpha-folate receptor (alpha-FR), a low capacity folate transporter that is highly overexpressed in some epithelial tumors. The role of alpha-FR in the activity of the antifolates has been evaluated in two alpha-FR-overexpressing cell lines grown in a physiological concentration of folate (20 nM R,S… CONTINUE READING