The role of alpha-CaMKII autophosphorylation in neocortical experience-dependent plasticity.

@article{Glazewski2000TheRO,
  title={The role of alpha-CaMKII autophosphorylation in neocortical experience-dependent plasticity.},
  author={Stanislaw Glazewski and Karl Peter Giese and Alcino Lazaro da Silva and Kevin Fox},
  journal={Nature neuroscience},
  year={2000},
  volume={3 9},
  pages={911-8}
}
Calcium/calmodulin kinase type II (CaMKII) is a major postsynaptic density protein. CaMKII is postulated to act as a 'molecular switch', which, when triggered by a transient rise in calcium influx, becomes active for prolonged periods because of its ability to autophosphorylate. We studied experience-dependent plasticity in the barrel cortex of mice carrying a point mutation of the alpha-CaMKII gene (T286A), which abolishes this enzyme's ability to autophosphorylate. Plasticity was prevented in… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…