The role of alpha(5)beta(1)-integrin in the IGF-I-induced migration of extravillous trophoblast cells during the process of implantation.

@article{KabirSalmani2004TheRO,
  title={The role of alpha(5)beta(1)-integrin in the IGF-I-induced migration of extravillous trophoblast cells during the process of implantation.},
  author={Maryam Kabir-Salmani and Shigetatsu Shiokawa and Yoshihiro Akimoto and Keiji Fujihara Akihiro Sakai and Mitsutoshi Iwashita},
  journal={Molecular human reproduction},
  year={2004},
  volume={10 2},
  pages={91-7}
}
The role of integrins in the processes of adhesion and migration makes them attractive potential participants in the complex events of embryo implantation and placentation. Recently, the role of the alpha(v)beta(3)-integrin pathway was shown in the insulin-like growth factor-I (IGF-I)-stimulated migration of extravillous trophoblast (EVT) cells. This study was designed to investigate the role of alpha(5)beta(1)-integrin in this respect. Using cultured EVT cells, migration assays were carried… CONTINUE READING