The role of aldosterone in potassium tolerance: studies in anephric humans.

@article{Sugarman1988TheRO,
  title={The role of aldosterone in potassium tolerance: studies in anephric humans.},
  author={Alison Sugarman and Robert S Brown},
  journal={Kidney international},
  year={1988},
  volume={34 3},
  pages={397-403}
}
Since the role of aldosterone in mediating extrarenal potassium transport remains uncertain, the effect of mineralocorticoid on potassium metabolism was assessed in anephric patients. Seven anephric patients underwent three identical 72-hour periods between hemodialyses during which treatment with either 10 mg/day deoxycorticosterone acetate (DOCA) intramuscularly or 300 mg/day spironolactone orally was compared to a baseline control period. The serum potassium rise, plasma aldosterone… CONTINUE READING

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