The role of aldosterone in potassium tolerance: studies in anephric humans.

@article{Sugarman1988TheRO,
  title={The role of aldosterone in potassium tolerance: studies in anephric humans.},
  author={Allison Sugarman and R. S. Brown},
  journal={Kidney international},
  year={1988},
  volume={34 3},
  pages={
          397-403
        }
}
Since the role of aldosterone in mediating extrarenal potassium transport remains uncertain, the effect of mineralocorticoid on potassium metabolism was assessed in anephric patients. Seven anephric patients underwent three identical 72-hour periods between hemodialyses during which treatment with either 10 mg/day deoxycorticosterone acetate (DOCA) intramuscularly or 300 mg/day spironolactone orally was compared to a baseline control period. The serum potassium rise, plasma aldosterone… 
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Hormonal and acidotic effects on the extrarenal potassium metabolism, in selected, anuric and stable, hemodialysis patients, and drugs affecting aldosterone action significantly influenced potassium metabolism were studied.
Extrarenal Effects of Aldosterone on Potassium Homeostasis.
TLDR
The aggregate data support a contributory role of aldosterone along with insulin and catecholamines in the normal physiologic regulation of internal K+ distribution and speculate differences in tissue sensitivity to ald testosterone may also contribute to differential tissue response of cardiac and skeletal muscle to conditions of total body K+ depletion.
Renin-Angiotensin-Aldosterone System Mechanisms of Impaired Potassium Handling With Dual Renin-Angiotensin-Aldosterone Blockade in Chronic Kidney Disease
TLDR
This study suggests that dual renin-angiotensin-aldosterone blockade may impair extrarenal/transcellular potassium disposition in addition to reducing potassium excretion in humans with renal impairment, and that acute changes in dynamic potassium handling are predictive of chronic changes in ambulatory potassium concentration with dual ren in-ang Elliotensinaldosterone blockade.
Diltiazem enhances potassium disposal in subjects with end-stage renal disease.
  • R. Solomon, A. Dubey
  • Medicine, Biology
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1992
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