The role of aldosterone blockade in murine lupus nephritis

@article{Monrad2008TheRO,
  title={The role of aldosterone blockade in murine lupus nephritis},
  author={Seetha U Monrad and Paul D. Killen and Marc R. Anderson and Amanda Bradke and Mariana J Kaplan},
  journal={Arthritis Research & Therapy},
  year={2008},
  volume={10},
  pages={R5 - R5}
}
BACKGROUND The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB x NZW) F1 murine lupus model. METHODS Female NZB/W F1 mice (11 weeks old) were treated daily with 25 or 50 mg/kg oral spironolactone or vehicle. Proteinuria, renal function, and serum autoantibody levels were monitored. Renal histopathology, immune complex deposition, and immunohistochemistry were analyzed at various time points… CONTINUE READING
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