The role of aldehyde oxidase in drug metabolism.

  title={The role of aldehyde oxidase in drug metabolism.},
  author={Enrico Garattini and Mineko Terao},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={8 4},
INTRODUCTION Aldehyde oxidases (AOXs) are molybdo-flavoenzymes with complex evolutionary profiles, as the number and types of active AOX genes vary according to the animal species considered. Humans and higher primates have a single functional AOX1 gene, while rodents are endowed with four AOXs. Along with the endoplasmic cytochrome P450 system (CYP450), cytoplasmic AOX1 is the major enzyme involved in the hepatic phase I metabolism of numerous xenobiotics. AREAS COVERED The authors review… CONTINUE READING
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