The role of aldehyde oxidase in drug metabolism.

@article{Garattini2012TheRO,
  title={The role of aldehyde oxidase in drug metabolism.},
  author={Enrico Garattini and Mineko Terao},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2012},
  volume={8 4},
  pages={487-503}
}
INTRODUCTION Aldehyde oxidases (AOXs) are molybdo-flavoenzymes with complex evolutionary profiles, as the number and types of active AOX genes vary according to the animal species considered. Humans and higher primates have a single functional AOX1 gene, while rodents are endowed with four AOXs. Along with the endoplasmic cytochrome P450 system (CYP450), cytoplasmic AOX1 is the major enzyme involved in the hepatic phase I metabolism of numerous xenobiotics. AREAS COVERED The authors review… CONTINUE READING
54 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Similar Papers

Loading similar papers…