The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes.

@article{Cusi2010TheRO,
  title={The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes.},
  author={Kenneth Cusi},
  journal={Current diabetes reports},
  year={2010},
  volume={10 4},
  pages={306-15}
}
The widespread epidemics of obesity and type 2 diabetes mellitus (T2DM) suggest that both conditions are closely linked. An increasing body of evidence has shifted our view of adipose tissue from a passive energy depot to a dynamic "endocrine organ" that tightly regulates nutritional balance by means of a complex crosstalk of adipocytes with their microenvironment. Dysfunctional adipose tissue, particularly as observed in obesity, is characterized by adipocyte hypertrophy, macrophage… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 107 extracted citations

Similar Papers

Loading similar papers…