The role of adiponectin in cholesterol efflux and HDL biogenesis and metabolism

@article{Hafiane2019TheRO,
  title={The role of adiponectin in cholesterol efflux and HDL biogenesis and metabolism},
  author={A. Hafiane and Karina Gasbarrino and Stella S. Daskalopoulou},
  journal={Metabolism},
  year={2019}
}
A Potential Interplay between HDLs and Adiponectin in Promoting Endothelial Dysfunction in Obesity
TLDR
A narrative review of the role of LGCI in altering HDLs, adiponectin and endothelial functions in obesity to encourage new studies about their synergic effects on cardiovascular health and disease.
Improvements in cholesterol efflux capacity of HDL and adiponectin contribute to mitigation in cardiovascular disease risk after bariatric surgery in a cohort with morbid obesity
TLDR
Improvements in CEC, through improvement in adipose tissue health in terms of adipokine secretion and insulin sensitivity could be an important pathway in modulating obesity-related CVD risk.
Shen-Hong-Tong-Luo Formula Attenuates Macrophage Inflammation and Lipid Accumulation through the Activation of the PPAR-γ/LXR-α/ABCA1 Pathway
TLDR
Results indicated that SHTL pretreatment reduced inflammation and lipid accumulation of macrophages by activating the PPAR-γ/LXR-α/ABCA1 pathway, which may provide a new insight into the mechanism of SHTL in the suppression of AS progression.
Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells
TLDR
The most updated findings of lipid metabolic abnormalities in CSCs are summarized and the potential applications of targeting lipid metabolism for anticancer treatment are prospected.
Obesity , adipose tissue types and adipocytokines ( Review of Articles )
TLDR
This review of the recent findings of the types of adipose tissue and their role in controlling metabolism, focusing on its endocrine function describes the molecular actions and clinical significance of the some important adipocytokines.
Hypoadiponectinemia and high TG/HDLc ratio as risk markers of insulin resistance in obese PCOS women
TLDR
Adiponectin and TGL:HDLc ratio are useful markers of insulin resistance that relates to the threat of cardiovascular diseases in obese women with PCOS.
Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial
TLDR
Serum adiponectin, a set of biomarkers related to glucolipid metabolism, anthropometric parameters, dietary intake and physical activity were measured before and after intervention and anthocyanins supplementation for 12 weeks improved serum adip onectin and fasting glucose in patients with newly diagnosed diabetes, but not in Patients with prediabetes.
...
...

References

SHOWING 1-10 OF 121 REFERENCES
Abstract 28: Adiponectin Stimulates Cholesterol Efflux Efficiently in Human THP-1 Macrophages and Modulates HDL-apoA-I Biogenesis
TLDR
In addition to promoting macrophage cholesterol efflux in vitro, APN can modulate HDL-apoA-I biogenesis, by increasing the generation of nHDL particles.
Adiponectin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in RAW 264.7 macrophages.
TLDR
Adiponectin up-regulates ABCA1 expression via the LXRα pathway in RAW 264.7 macrophages in a dose-dependent and time-dependent manner, which could prove useful for developing new treatment strategies for cardiovascular diseases.
Effects of macrophage-specific adiponectin expression on lipid metabolism in vivo.
TLDR
Results indicate that macrophages engineered to produce adiponectin can influence in vivo gene expression in adipose tissue in a manner that reduces inflammation and macrophage infiltration and in liver tissue inA manner that alters the circulating lipoprotein profile, resulting in a decrease in VLDL and LDL and an increase in HDL cholesterol.
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases
TLDR
It is found that decreased high molecular weight (HMW) adiponectin plays a crucial and causal role in obesity-linked insulin resistance and metabolic syndrome, and that AdipoR1 and AdIPoR2 serve as the major AdipORs in vivo.
...
...