The role of adipokines in β-cell failure of type 2 diabetes.

@article{Dunmore2013TheRO,
  title={The role of adipokines in β-cell failure of type 2 diabetes.},
  author={Simon J Dunmore and James E. P. Brown},
  journal={The Journal of endocrinology},
  year={2013},
  volume={216 1},
  pages={T37-45}
}
β-Cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review, we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of β-cells, focusing on those reported to have the most significant effects… CONTINUE READING