The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease--1990 update.

@article{Nickoloff1990TheRO,
  title={The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease--1990 update.},
  author={Brian J. Nickoloff and Christopher Griffiths and Jonathan N. W. N. Barker},
  journal={The Journal of investigative dermatology},
  year={1990},
  volume={94 6 Suppl},
  pages={151S-157S}
}
In 1986 it was discovered that cultured human keratinocytes, when treated with gamma interferon, attract and bind T lymphocytes and monocytes. More is now known about trafficking of inflammatory cells in the skin, with specific molecular details involving various cytokines, chemotactic factors, and adhesion molecules. One key element is the in vivo movement of T cells that express LFA-1 into the epidermis, and their subsequent binding to keratinocytes via the surface expression of intercellular… CONTINUE READING
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