The role of activation-induced deaminase in lupus nephritis.

@article{Diaz2013TheRO,
  title={The role of activation-induced deaminase in lupus nephritis.},
  author={Marilyn Diaz},
  journal={Autoimmunity},
  year={2013},
  volume={46 2},
  pages={115-20}
}
High affinity autoreactive IgG antibodies have been implicated in the development of lupus nephritis and other autoimmune disorders. With the discovery of activation-induced deaminase (AID), this question could be finally tested by examining the impact of AID deficiency in autoimmune-prone mice like the MLR/lpr strain. We have recently shown that AID-deficient MRL/lpr mice experienced a complete abrogation of lupus nephritis, and increased survival despite a dramatic increase in autoreactive… CONTINUE READING

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We have recently shown that AID - deficient MRL / lpr mice experienced a complete abrogation of lupus nephritis , and increased survival despite a dramatic increase in autoreactive IgM. Subsequent studies demonstrated that anti - dsDNA IgM is not pathogenic and in fact protects MRL / lpr from glomerulonephritis .
We have recently shown that AID - deficient MRL / lpr mice experienced a complete abrogation of lupus nephritis , and increased survival despite a dramatic increase in autoreactive IgM. Subsequent studies demonstrated that anti - dsDNA IgM is not pathogenic and in fact protects MRL / lpr from glomerulonephritis .
We have recently shown that AID - deficient MRL / lpr mice experienced a complete abrogation of lupus nephritis , and increased survival despite a dramatic increase in autoreactive IgM. Subsequent studies demonstrated that anti - dsDNA IgM is not pathogenic and in fact protects MRL / lpr from glomerulonephritis .
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