The role of acetaldehyde in upper digestive tract cancer in alcoholics.

@article{Seitz2007TheRO,
  title={The role of acetaldehyde in upper digestive tract cancer in alcoholics.},
  author={Helmut Karl Seitz and Patrick Meier},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2007},
  volume={149 6},
  pages={293-7}
}
Chronic excessive alcohol consumption is the strongest risk factor for upper aerodigestive tract (UADT) cancer. Multiple mechanisms are involved in alcohol-associated cancer development of the UADT, including acetaldehyde (AA) effects. AA is toxic, mutagenic, and carcinogenic. Evidence of the role of AA in alcohol-associated carcinogenesis derived from genetic linkage studies in alcoholics. Polymorphism or mutation in genes coding for AA generation or detoxification enzymes are associated with… CONTINUE READING