The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes

@article{Nolte2003TheRO,
  title={The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes},
  author={Christof Nolte and Angel Amores and Erzs{\'e}bet Nagy Kov{\'a}cs and John H Postlethwait and M. Featherstone},
  journal={Mechanisms of Development},
  year={2003},
  volume={120},
  pages={325-335}
}
The zebrafish hoxd4a locus was compared to its murine ortholog, Hoxd4. The sequence of regulatory elements, including a DR5 type retinoic acid response element (RARE) required for Hoxd4 neural enhancer activity, are highly conserved. Additionally, zebrafish and mouse neural enhancers function identically in transgenic mouse embryos. We tested whether sequence conservation reflects functional importance by altering the spacing and sequence of the RARE in the Hoxd4 neural enhancer. Stabilizing… CONTINUE READING

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The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms

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