The role of a non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis

Abstract

Signaling by cytokines such as the interferons (IFNs) involves Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) transcription factors. The beauty of the classical model of JAK-STAT signaling is its simplicity in that JAK-activated STATs in the nucleus are responsible for specific gene activation. The fact that many ligands… (More)
DOI: 10.4161/jkst.26227

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