The role of a cell-associated hyaluronan-binding protein in fibroblast behaviour.

@article{Turley1989TheRO,
  title={The role of a cell-associated hyaluronan-binding protein in fibroblast behaviour.},
  author={Eva Ann Turley},
  journal={Ciba Foundation symposium},
  year={1989},
  volume={143},
  pages={121-33; discussion 133-7, 281-5}
}
In a model culture system hyaluronan has been shown to promote cell ruffling and random cell locomotion. At the same time it promotes both protein tyrosine phosphorylation and phospholipid breakdown. These results indicate that this glycosaminoglycan, in addition to its previously described role as a regulator of adhesion and cytoskeletal organization, may also influence cell behaviour via second messenger formation. A cell-associated hyaluronan-binding protein (cell-HABP) has been isolated… CONTINUE READING