The role of Y chromosome deletions in male infertility.

  title={The role of Y chromosome deletions in male infertility.},
  author={Kun Ma and Con Mallidis and Shalendar Bhasin},
  journal={European journal of endocrinology},
  volume={142 5},
Male infertility affects approximately 2-7% of couples around the world. Over one in ten men who seek help at infertility clinics are diagnosed as severely oligospermic or azoospermic. Recent extensive molecular studies have revealed that deletions in the azoospermia factor region of the long arm of the Y chromosome are associated with severe spermatogenic impairment (absent or severely reduced germ cell development). Genetic research into male infertility, in the last 7 years, has resulted in… CONTINUE READING


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