The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning.

@article{Kazanskaya2000TheRO,
  title={The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning.},
  author={Olga Kazanskaya and Andrei Glinka and Christof Niehrs},
  journal={Development},
  year={2000},
  volume={127 22},
  pages={4981-92}
}
Dickkopf1 (dkk1) encodes a secreted WNT inhibitor expressed in Spemann's organizer, which has been implicated in head induction in Xenopus. Here we have analyzed the role of dkk1 in endomesoderm specification and neural patterning by gain- and loss-of-function approaches. We find that dkk1, unlike other WNT inhibitors, is able to induce functional prechordal plate, which explains its ability to induce secondary heads with bilateral eyes. This may be due to differential WNT inhibition since dkk1… CONTINUE READING
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